Assessing the Carcinogenic Potential of Low-Dose Exposures to Chemical Mixtures in the Environment: The Challenge Ahead
Special edition of Carcinogenesis, June 2015
The Halifax Project, organized by Getting to Know Cancer investigated the hypothesis that chemicals not known to cause cancer on their own could work synergistically to cause cancer by disrupting essential cellular pathways.
Project leaders Leroy Lowe and Michael Gilbertson recruited 176 scientists from many fields, including cancer biology, toxicology, and epidemiology, divided them up into teams -- one for each of the Hallmarks of Cancer outlined by the groundbreaking work of Douglas Hanahan of the University of California – San Francisco and Robert A. Weinberg of the Massachusetts Institute of Technology. Each team dug into scientific literature, searching for instances where each of 85 chemicals under investigation interacted with essential pathways. Last year’s special edition of the journal Carcinogenesis contains 11 review articles and a capstone paper summarizing the Halifax Project’s findings, initially published in 2012.
Dr. Curt DellaValle, July 2015
EWG Senior Scientist Dr. Curt DellaValle expanded on the work of the Halifax Project by looking in human biomonitoring studies for evidence of the 85 Halifax Project chemicals and discussing the implications.
Reducing Environmental Cancer Risk: What We Can Do Now
President Cancer Panel Report, 2009
The 2008-2009 President’s Cancer Panel, co-chaired by Dr. Margaret Kripke, investigated environmental contaminants and their potential to contribute to cancer. The report urges the President to focus research and regulation on reducing environmental exposures.